Our Science

Overcoming the challenges of drugging intracellular targets

Vesigen’s therapeutic programs employ engineered ARMMs to deliver RNA, proteins, and gene-editing complexes to cells that are not otherwise accessible. Unlike existing delivery systems, which are limited by toxicity, immunogenicity, poor cell/tissue specificity, and reduced cellular activity due to endosomal trapping or endolysosomal processing, ARMMs technology overcomes these limitation to achieve safe and efficient functional delivery of therapeutic molecules.

Extracellular vesicles and ARMMs technology

Our technology is based on a distinct class of extracellular vesicles that mediates inter-cellular and inter-tissue signaling within the human body. ARMMs (ARRestin-domain 1 Mediated Microvesicles) technology derives its name from the protein ARRestin Domain Containing Protein 1 (ARRDC1), and utilizes the latter protein as a unique handle to actively recruit payloads into the intraluminal space.

ARMMs mediate intercellular communication. We leverage this delivery mechanism to enable a range of therapeutic applications.

Precision Medicines Enabled

Engineered ARMMs present a versatile platform for therapeutic delivery, overcoming the limitations of existing technologies such as toxicity, low specificity, instability, and high immunogenicity associated with lipid nanoparticles (LNPs), viral vectors, transducing peptides, and nano-carriers.

Vesigen’s ARMMs technology offers significant advantages over exosomes, LNPs, penetrating peptides, and viral delivery systems:

Tissue-specific distribution observed in vivo
Streamlined payload production and formulation in a single process
Scalable production capabilities utilizing common upstream and downstream biologics process technologies
Superior engineerability (intraluminal and extravesicular) with broad therapeutic applications

Engineered cells producing ARMMs loaded with green fluorescent protein (GFP)

Uptake of GFP-loaded ARMMs by recipient cells

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