Careers
Join a team of inspired drug hunters
Looking for the next step up in your career? Vesigen is on a mission to uncover new opportunities across a vast therapeutic landscape made possible by ARMMs technology.
At Vesigen, you’ll join a rapidly growing biotech company at the forefront of discovery. We are a collective of inspired drug hunters committed to creating solutions to current challenges in drug development.
We value scientific curiosity and teamwork from start to finish. If you share these attributes and you’re ready for the challenge of your career, we’d like to hear from you.
VP, Biology and Drug Discovery
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique and fusogenic extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles), delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Responsibilities
Qualifications
Vesigen Therapeutics is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
Sci II/Senior Scientist, ARMMs Engineering
Vesigen Inc., is a biotechnology company developing transformative therapies using a unique extracellular vesicle delivery technology. Our ARMMs (ARRDC1 Mediated Microvesicles) technology, delivers payloads, including proteins, genome editing machineries, and RNA molecules directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging ARMMs to develop medicines and address currently unmet medical needs.
Vesigen is seeking a talented and highly motivated Scientist II/Sr Scientist to join our team and contribute to the development of the company’s exciting ARMMs technology across multiple disease areas. The ideal candidate will have an established background in molecular biology, vector design and optimization, membrane protein biology, and antibody engineering. This is an opportunity to innovate and impact preclinical drug discovery efforts in a dynamic biotech start-up environment.
Responsibilities:
Develop appropriate assays to evaluate new constructs and strategies to modify various ARMMs properties.
Qualifications:
Vesigen Inc., is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
Scientist/Sr Scientist, Ocular Drug Discovery
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutics using a unique and fusogenic extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles), delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs in ophthalmology. Vesigen is seeking an analytical and highly motivated Scientist to join our Ocular and CNS Drug Discovery team to help drive ophthalmology-centric preclinical programs with the company’s ARMMs technology. The candidate will play a significant role in the entire spectrum of the drug discovery process including ideation, target identification & validation, and disease-related biomarkers.
Responsibilities
· Expand, strengthen, and fine-tune our current ocular biodistribution datasets in diverse in vivo models using multiple routes-of-administration and payloads/modalities. You will conduct routine subretinal/intravitreal surgeries in rodents on-site and manage CROs for specialized surgeries in large animal models.
· Conceptualize, design, and execute experiments independently.
· Maintain accurate experimental records and study reports. Ensure that discovery work and data collection are conducted with utmost attention to quality and ethical standards and, in compliance with regulatory and QC guidelines.
· Routinely implement histology, non-invasive diagnostics, electrophysiology, and behavior assays to assess ocular biodistribution, toxicological outcomes, and efficacy.
· Work closely with colleagues in biology, computational biology, and therapeutic discovery group for design and screening of ARMMs for ocular drug candidates. You will be part of a group effort and help select appropriate assays, and in vitro, ex vivo & in vivo screening criteria. You will participate in the screening campaigns and importantly, help generate high-confidence data that are substantiated by in vivo findings.
· Facilitate and maintain relationships with CROs, external academic groups, and scientific and key opinion leaders. Coordinate study design and execution, manage timelines, and data quality control. Analyze and present findings to various stakeholders.
· Present research findings to the Vesigen Leadership and various stakeholders
· Attend scientific and industry conferences to engage the broader scientific community.
Qualifications
· Ph.D. in Ophthalmology/Neuroscience/Neurobiology with relevant surgical experience or a Ph.D. with 2+ years of relevant experience in industry or academia.
· Deep expertise and understanding of degenerative pathophysiology, animal models, and an experience in using these animal models to assess therapeutic outcomes.
· Experience in conducting in vivo, ex vivo, and in vitro experiments – in ophthalmology using intravitreal and subretinal routes of administration.
· Ability to conduct in vivo studies using rodent model systems. An ideal candidate will demonstrate a deep understanding of comparative ocular anatomy, pathophysiology, proficiency and independence in the laboratory, experience in ocular drug delivery, small animal surgical skills in ophthalmology, and a proven ability to complete ocular drug discovery projects.
· Proficiency in histology (including sections and flatmount preparations of the retina and the RPE), immunohistochemistry, and cell culture is expected. Hands-on experience with confocal imaging, quantitative image analysis, and quantitative RNA in situ hybridization is highly desirable but not an absolute must.
· Demonstratable experience of working independently as well as a member of the team on scientific projects.
· Excellent communication and organizational skills.
· Ability to quickly learn and pivot as guided by data. Candidates with a strong background in CNS drug delivery and discovery, surgery, and an understanding of retinal anatomy & physiology are welcome to apply.
Vesigen Therapeutics is an equal-opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
RA I/II Drug Discovery
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles), delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Vesigen is seeking a creative and highly motivated Research Associate I/II to join our team to help advance the company’s exciting ARMMs technology through preclinical in vivo studies in Drug Discovery. The candidate will be an integral member of the R&D team, with opportunities to learn and contribute and develop preclinical programs across several therapeutic areas. Candidates with Ocular and/or Neuroscience experience are especially encouraged to apply.
Responsibilities:
· Perform preclinical Pharmacology and Toxicological studies in rodents. Tasks includes assistance with drug administration via multiple routes (systemic, ocular or CNS), blood and tissue collection.
· Histology: Perform tissue collection, processing and preparation for histology studies including paraffin and cryosectioning, whole mount preparation and staining.
· Perform immunohistochemistry, image acquisition and data analysis.
· Isolation and maintenance for primary cells from rodents for drug screening and assays.
· Responsible for working with the Ocular and CNS Drug Discovery team to design, implement, and follow study protocols.
· Assist with rodent colony management, husbandry, and record-keeping.
· Collect, codify, and present data findings to the internal R&D team.
· Additional related responsibilities as assigned.
Qualifications:
· Bachelor’s degree in biology, pharmacology, or related discipline or an Associate’s degree in Laboratory Animal Science/Technology or related science discipline with 2+ years of experience in animal handling, dosing, dissections and histology.
· Prior experience with histopathology and/or toxicology especially in industry setting is highly desirable.
· Proficiency in tissue collection, fixation and processing for histology (Cryosectioning and/or Paraffin). Hands-on experience with histology (sectioning and staining) is required.
· Adept in basic rodent techniques: whole-animal cardiac perfusions, blood collection via tail and/or submandibular vein, cardiac puncture; euthanasia, etc.
· Experience in dosing via ocular (subretinal, intravitreal, intracameral, suprachoroidal) or CNS (ICM, ICV, intraparenchymal, intrathecal) is highly desirable.
· Experience with tissue collection from PK studies and preparing samples for histological, biochemical and immunological assays.
· Experience with rodent colony management, including animal health checks, record keeping, etc.
· Experience with aseptic cell culture, isolation and maintenance of primary cells (especially from the eye or the CNS) is preferred, but not required.
· Prior experience with microscopy (fluorescence, confocal, slide scanner) is highly desirable.
· Well-organized, methodical, and ability to document experimental observations and results in a timely manner.
· Strong written and oral communication skills with the ability to multitask with an evolving workload.
· Team player, ability to collaborate effectively within a fast-paced, multidisciplinary environment.
· Motivated, self-starter with enthusiasm to learn.
Vesigen Therapeutics is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
Downstream Process Development Associate
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique, fusogenic extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles) delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Vesigen is seeking a highly motivated and detail-oriented Downstream PD Associate to join our team and contribute to the development and optimization of the company’s exciting ARMMs platform. The ideal candidate will have process development experience with an understanding of the production and quality control of biopharmaceuticals to enable drug discovery efforts.
Responsibilities:
Required
Preferred
Vesigen Therapeutics is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
Don’t see anything that matches your experience? Contact us using the form.
Dieter Weinand
Board Member