Careers
Join a team of inspired drug hunters
Looking for the next step up in your career? Vesigen is on a mission to uncover new opportunities across a vast therapeutic landscape made possible by ARMMs technology.
Work at the forefront
At Vesigen, you’ll join a rapidly growing biotech company at the forefront of discovery. We are a collective of inspired drug hunters committed to creating solutions to current challenges in drug development.
We value scientific curiosity and teamwork from start to finish. If you share these attributes and you’re ready for the challenge of your career, we’d like to hear from you.
Current opportunities
Open Positions
VP, Biology and Drug Discovery
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique and fusogenic extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles), delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Responsibilities
- Work closely with executive management team to prioritize and advance preclinical drug development programs from concept through IND submission
- Articulate vision, strategy and performance metrics for platform and drug discovery arms at Vesigen
- Manage all ARMMs engineering and drug discovery functions to develop existing programs, establish go/no-go decision points, introduce new programs, and to identify new opportunities to expand scope of current programs
- Lead scientific activities with strong attention to rigor and differentiation to permit advancing drug candidates as first-in-class/best-in-class therapies for diseases with unmet need
- Track literature and identify opportunities to introduce new design strategies and/or applications for ARMMs
- Implement and help inform intellectual property strategy, working closely with executive management and IP teams
- Work with CROs, academic collaborators, and other biotech/pharma companies
- Assist in projecting resources and financial budgets to support discovery programs from the exploratory stage through the development stage to clinical
Qualifications
- PhD/MD with strong background in Molecular Biology, Cell Biology, Virology, Immunology, Pharmacology, or related field
- 10+ years of experience in drug discovery, platform development, or combination thereof in biotech or pharma
- Proven track record leading teams in platform development and/or drug discovery settings – experience with viral and/or non-viral delivery and/or platform builds desirable
- Demonstrated expertise and track record in drug discovery in a range of therapeutic areas, ideally from conceptualization through lead optimization and candidate selection
- Track record of excellence and scientific expertise as demonstrated by peer-reviewed publications
- High level of rigor and attention to detail, and ability to think out of the box and innovate
- Strong leadership, communication skills, and ability to perform at a high level in a fast-paced environment
Vesigen Therapeutics is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
Sci II/Senior Scientist, ARMMs Engineering
Vesigen Inc., is a biotechnology company developing transformative therapies using a unique extracellular vesicle delivery technology. Our ARMMs (ARRDC1 Mediated Microvesicles) technology, delivers payloads, including proteins, genome editing machineries, and RNA molecules directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging ARMMs to develop medicines and address currently unmet medical needs.
Vesigen is seeking a talented and highly motivated Scientist II/Sr Scientist to join our team and contribute to the development of the company’s exciting ARMMs technology across multiple disease areas. The ideal candidate will have an established background in molecular biology, vector design and optimization, membrane protein biology, and antibody engineering. This is an opportunity to innovate and impact preclinical drug discovery efforts in a dynamic biotech start-up environment.
Responsibilities:
- Expression construct design and optimization to evaluate engineering of ARMMs intraluminal payloads and targeting moieties (eg, antibodies, receptor ligands, etc…), including other vesicle surface-associated modifications.
- Custom design of vectors to enable rapid swapping of elements for optimization of transgene expression or to alter other elements, such as linkers.
- Execute and oversee testing of constructs by transient transfection using approaches such as PEI, lipoplex, or electroporation
Develop appropriate assays to evaluate new constructs and strategies to modify various ARMMs properties.
- Contribute to design of assays to support platform and discovery activities, as they relate to vector design, including appropriate evaluation of transgene expression, payloading/surface modification of ARMMs, and determination of particle potency.
- Analyze and present experimental progress and results in team meetings.
- Collaborate across research function and with process development team to enable transfer of knowhow and scale-up of engineered ARMMs production.
Qualifications:
- Ph.D. in molecular biology, protein biochemistry, virology or related life sciences field and 0-5 years of hands-on industry experience strongly preferred. B.S./M.S. with 10 or more years of relevant experience will also be considered for the role.
- Excellent understanding of membrane protein structure and antibody engineering including scFv (single chain variable fragment) and nanobodies.
- Previous experience in molecular mechanisms of virus-host interactions highly desirable
- Extensive experience in molecular biology and with relevant online tools and software packages eg: SnapGene or similar software.
- Experience with construct design, introduction into the model system/cell line, including transfection, transduction, and electroporation.
- Strong background in cell-based assays and readouts by flow cytometry, qPCR, Western Blot, ELISA, and high-content imaging.
- Experience in and/or commitment to training and mentoring junior team members
- Ability to collaborate effectively within a fast-paced, multidisciplinary environment.
- Excellent organizational skills and record keeping.
- Good written and oral communication skills and the ability to multitask with an evolving workload.
- Motivated, self-starter with enthusiasm to learn and contribute.
Vesigen Inc., is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
To apply, use the form below.
Don’t see anything that matches your experience? Contact us using the form.
The ARMMs technology presents a unique opportunity to transition innovative technologies into viable drug leads needed within the pharmaceutical industry and ultimately transform patient care.
Dieter Weinand
Board Member
Vesigen Therapeutics
790 Memorial Drive
Suite 103
Cambridge, MA 02139
