Careers
Join a team of inspired drug hunters
Looking for the next step up in your career? Vesigen is on a mission to uncover new opportunities across a vast therapeutic landscape made possible by ARMMs technology.
Work at the forefront
At Vesigen, you’ll join a rapidly growing biotech company at the forefront of discovery. We are a collective of inspired drug hunters committed to creating solutions to current challenges in drug development.
We value scientific curiosity and teamwork from start to finish. If you share these attributes and you’re ready for the challenge of your career, we’d like to hear from you.
Current opportunities
Open Positions
Sci II, Sr Scientist Extracellular Vesicle Engineer (Molecular Biology)
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs (ARRDC1 Mediated Microvesicles) technology, delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Vesigen is seeking a talented and highly motivated Scientist to join our team and contribute to the development of the company’s exciting ARMMs technology across multiple disease areas. The ideal candidate will have an established background in molecular biology, vector design, optimization, and testing. This is an opportunity to innovate and impact preclinical drug discovery efforts in a dynamic biotech start-up environment.
Responsibilities:
- Lead vector design and optimization through integration and alteration of various regulatory/promoter elements and linkers to design payloading constructs or to enable other strategies.
- Custom design of vectors to enable rapid swapping of elements for optimization of transgene expression or to alter other elements within
- Execute and oversee testing of constructs by transient transfection using approaches such PEI, lipoplex, and electroporation.
- Design constructs for stable cell line generation using viral or non-viral approaches and generation of resultant cell lines.
- Contribute to design of analytical assays to support platform and discovery activities, as they relate to vector design, including appropriate evaluation of transgene expression, payloading of ARMMs, and corresponding activity of payload.
- Analyze and present experimental progress and results in team meetings.
- Work with process team to enable transfer of knowhow and scale-up of ARMMs production for any specific payload.
Qualifications:
- Ph.D. in molecular biology, pharmacology, chemistry or related life sciences field and 0-5 years of hands-on industry experience. B.S./M.S. with 5 or more years of relevant experience will also be considered for the role.
- Extensive experience in molecular biology and with relevant online tools and software packages eg: SnapGene or similar software
- Experience with construct design, introduction into the model system/cell line, including transfection, transduction, and electroporation.
- Strong background in cell-based assays and readouts by flow cytometry, qPCR, Western Blot, ELISA, and high-content imaging.
- Knowledge in RNA secondary structure prediction desirable
- Commitment to training and mentoring junior team members.
- Ability to collaborate effectively within a fast-paced, multidisciplinary environment.
- Excellent organizational skills and record keeping
- Good written and oral communication skills and the ability to multitask with an evolving workload.
- Motivated, self-starter with enthusiasm to learn and contribute.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Research Associate I-II, Tissue Culture Core
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique and fusogenic extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles), delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Vesigen is seeking a creative and highly motivated Research Associate to join our team and help advance the development of the company’s exciting ARMMs technology. The candidate will be an integral member of the R&D team, with opportunities to learn and contribute and develop numerous preclinical programs across several therapeutic areas.
Responsibilities:
- Culture, expand, and bank suspension and adherent cell lines in coordination with cell line development, downstream processing teams and other team members, as required.
- Harvest and process conditioned media to enable purification by downstream processing team.
- Perform and analyze cell and plate-based assays.
- Perform small and large scale mRNA/plasmid transfections using standard chemical transfection methods or by electroporation.
- Stock, prepare, and/or develop cell media to support tissue culture, in coordination with team leader and other colleagues.
- Maintain excellent records of experiments, production logs, inventory, and other relevant information.
- Collect, document observations and results, provide updates and present scientific findings to the R&D team.
Qualifications:
- Bachelor’s or Associate’s degree in biology or related discipline plus 3-5 years of hands-on experience in an academic or biotech research setting or Master’s degree plus 1-3 years of experience
- Strong core competencies in cell biology or other related discipline
- Experience/knowledge with cell culture platform to produce extracellular vesicles / exosomes or AAV preferred
- Hands on experience with development of cell culture protocols for adherent and suspension cells and with different platforms such as shaker flasks, spinner flasks, bioreactors, etc.
- Well organized with attention to detail, and ability to document experimental observations and results in a timely manner.
- Strong written and oral communication skills with the ability to multitask with an evolving workload.
- Ability to collaborate effectively within a fast-pace, multidisciplinary environment.
- Motivated, self-starter with enthusiasm to learn.
- Other duties, as assigned.
Downstream Process Development Scientist
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique, fusogenic extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles) delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Vesigen is seeking a creative and highly motivated Downstream PD Scientist to join our team and contribute to the development and optimization of the company’s exciting ARMMs platform. The ideal candidate will have process development experience with an understanding of the production and quality control of biopharmaceuticals to enable drug discovery efforts.
Responsibilities:
- Designs and characterizes new processes for extracellular vesicle purification from concept to scale-up.
- Follows SOPs to generate test articles for exploratory through preclinical studies.
- Performs isolation of extracellular vesicles by various methodologies such as chromatography, tangential flow filtration, and ultracentrifugation.
- Characterizes extracellular vesicles by nanoparticle tracking analysis, protein assay, simple western/western blot, real-time/ddPCR, ELISA, and/or other methods as appropriate.
- Independently designs, plans and executes studies in coordination with manager and cross-functional teams.
- Analyzes and presents data internally and at conferences.
- Maintains complete records of activities.
Required
- PhD in chemical engineering, pharmaceutical science, or related field, with 0-2 years of applicable experience in process development or production of biopharmaceuticals.
- Expertise with preparative chromatography and tangential flow filtration.
- Strong understanding of MS Office and statistical/graphing software such as GraphPad Prism.
Strongly Preferred
- Previous experience working in downstream bioprocessing in a GMP lab at bench or lab scale.
- Formulation, cryopreservation, and evaluation of stability of biologics.
- Hands on experience with instrumentation for analysis of extracellular vesicles.
- As an alternative to experience with extracellular vesicles, we will consider candidates with experience in bioprocessing/characterization of viral-like particles or AAV.
Accounting Associate/Accounts Payable
Accounting Associate/Accounts Payable
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique, fusogenic extracellular vesicle technology for delivery of therapeutic agents directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles) delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Vesigen is seeking a highly motivated and detailed oriented accounting and accounts payable professional to join our team and contribute to establishing the accounting department with the Director of Finance. This is an exciting opportunity to join a growing company and hone skills in providing financial, administrative, and clerical support to the organization. The ideal candidate will be a driven individual looking to work in a fast-paced, dynamic, biotech start-up environment.
Responsibilities
- Creating journal entries and financial reports
- Entering and paying bills in a timely manner and responding to all vendor inquiries regarding finance-related issues
- Approving purchase requisitions and ensuring that purchase orders are properly set up
- Keeping track of all payments and expenditures, purchase orders, invoices, and statements
- Reconciling credit card statements, including tying back receipts and coding transactions to appropriate general ledger accounts
- Setting up vendors in accounting software and reviewing AP ledger monthly
- Processing payroll and resolving any issues in a timely manner
- Entering new hires and terminations in payroll system
- Assisting the Controller with other tasks as needed
Qualifications
- Preferred: Bachelor of Science degree in Accounting, or similar degrees
- 1 – 2 years of experience with journal entries and accounts payable
- 1 – 2 years of experience using accounting software
- 1 – 2 years of experience using a payroll system
- Strong organizational skills and proactive in resolving any issues that may come up
- Attention to detail and sense of ownership
- Strong analytical and problem-solving skills
- Demonstrate ability to work independently and work well with people at a wide range of levels
- Experience in biotech industry is a plus
Vesigen Therapeutics is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
RA I/II, In-Vivo Pharmacology
Vesigen Therapeutics is a biotechnology company developing groundbreaking therapeutic products using a unique and fusogenic extracellular vesicle delivery technology directed to intracellular targets. Our ARMMs technology (ARRDC1 Mediated Microvesicles), delivers payloads, including RNAs, proteins, and editing complexes directly into the cytoplasm of target cells. Our team of seasoned drug hunters is committed to leveraging the novel ARMMs technology to develop transformative medicines and address currently unmet medical needs.
Vesigen is seeking a creative and highly motivated Research Associate I-II to join our team to help advance the company’s exciting ARMMs technology through preclinical in vivo studies. The candidate will be an integral member of the R&D team, with opportunities to learn and contribute and develop numerous preclinical programs across several therapeutic areas.
Responsibilities:
- Perform preclinical pharmacology studies in rodents. Tasks include drug administration via multiple routes (IV, IP, SC, PO etc.), blood and tissue collection.
- Responsible for working with the in vivo pharmacology team to develop in house disease models, troubleshooting histological problems, and follow study protocols.
- Collect, codify, and present data findings to the R&D team.
Qualifications:
- Bachelor’s degree in biology, pharmacology, or related discipline (preferred: an associate degree in Laboratory Animal Science/Technology or related science discipline)
- Minimum of 2+ years of experience in animal handling and dosing
- Motivated, self-starter with enthusiasm to learn
- Prepared to work collaboratively in a fast-paced, multidisciplinary environment
- Flexibility in work scheduling, depending on the timelines, readouts, and specific circumstances of a given animal study **Required: Occasional onsite weekend work may be scheduled as part of the standard 40-hour workweek**
- Proficiency in histopathology methods such as sectioning, staining, and imaging is highly desirable
- Experience with Disease models is PLUS
Vesigen Therapeutics is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
To apply, use the form below.
Don’t see anything that matches your experience? Contact us using the form.
The ARMMs technology presents a unique opportunity to transition innovative technologies into viable drug leads needed within the pharmaceutical industry and ultimately transform patient care.
Dieter Weinand
Board Member
Vesigen Therapeutics
790 Memorial Drive
Suite 103
Cambridge, MA 02139
